Layer V Neocortical Neurons From Individuals With Drug-Resistant Epilepsy Show Multiple Synaptic Alterations but Lack Somatic Hyperexcitability
Luis Alfredo Márquez, Christopher Martínez-Aguirre, Estefanía Gutiérrez-Castañeda, Ernesto Griego, Isabel Sollozo-Dupont, Félix I. López-Preza, Mario Alonso‐Vanegas, Luisa Lilia Rocha, Emilio J. Galván
The paper examines synaptic and electrophysiological properties of layer V pyramidal neurons in drug-resistant epilepsy patients, finding synaptic alterations rather than somatic hyperexcitability contribute to seizure activity.
PLoS ONE · Jan 27, 2026Peer-reviewedNeuroscience