This study investigates how antimony-resistant Leishmania donovani strains manage iron and oxidative stress, leading to anemia, and identifies potential therapeutic targets.

PLoS Pathogens · Jan 31, 2025Peer-reviewedMicrobiology

Mechanism of host cell invasion by Leishmania through KMP-11 mediated cholesterol-transport and membrane phase transition

Achinta Sannigrahi, Souradeepa Ghosh, Supratim Pradhan, Pulak Jana, Junaid Jibran Jawed, Subrata Majumdar, Syamal Roy, Sanat Karmakar, Budhaditya Mukherjee, Krishnananda Chattopadhyay

This paper identifies KMP-11 as a key Leishmania protein that mediates host cell invasion via cholesterol transport and membrane phase transition.

EMBO Reports · Oct 31, 2024Peer-reviewedBiophysics

AUF-1 knock down in mice overarches butyrate driven hypo-cholesteraemia by conjuring AUF-1-Dicer-1-miR122 hierarchy

Oishika Das, Jayanta Kundu, Atanu Ghosh, Anupam Gautam, Souradeepa Ghosh, Mainak Chakraborty, Aaheli Masid, Samiran Sona Gauri, Debmalya Mitra, Moumita Dutta, Budhaditya Mukherjee, Surajit Sinha, Moumita Bhaumik

The paper investigates how butyrate affects cholesterol levels through the AUF-1-Dicer-1-miR122 pathway in mice, showing that AUF-1 knockdown increases miR122 and reduces serum cholesterol.

bioRxiv · Jun 13, 2022 · PreprintSystems Biology