Author

Cheng-Han Ho

Institute for Quantitative Biosciences, The University of TokyoORCID 0000-0002-7350-6200Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ChIP-seq· 1

Frequent Co-Authors

Haruhiko EharaiD· 2 shared Hitoshi KurumizakaiD· 2 shared Mitsuo OgasawaraiD· 2 shared Shun‐ichi SekineiD· 2 shared Tomoya KujiraiiD· 2 shared Yoshimasa TakizawaiD· 2 shared Hiroki Tanaka· 1 shared K. NozawaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersMolecular Biology

Haruhiko EharaORCID

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2 papers

Recent·Most cited

Molecular BiologyNature Structural & Molecular BiologyPeer-reviewedJun 25, 2026

Structural basis of asymmetric transcription through a composite nucleosome formed by a hexasome and an octasome

Zhihui Chen, Cheng-Han Ho, Hiroki Tanaka…·Hitoshi Kurumizaka

The paper investigates how RNA polymerase II transcribes through an OLDN, finding higher efficiency from the hexasome side and revealing conformational changes during transcription.

DOI 10.1038/s41594-026-01837-0

ChIP-seqexperimental assay

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Molecular BiologybioRxivPreprintMay 13, 2025

Structural basis of RNA polymerase II transcription on the H3-H4 octasome

Cheng-Han Ho, K. Nozawa, Masahiro Nishimura…·Hitoshi Kurumizaka

This study shows that RNA polymerase II transcribes the H3-H4 octasome more efficiently than the nucleosome, with distinct pausing patterns and stepwise tetramer disassembly.

DOI 10.1101/2025.05.13.653634

experimental assay

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