Structural basis of lenacapavir-induced HIV-1 capsid disruption during virion maturation
Hiroki Tanaka, Reina Morita, Tomomasa Oka, Minoru Fukushima, Shunsuke Kita, Mina Sasaki, Katsumi Maenaka, Shinichi Machida
This study determines the cryo-EM structure of HIV-1 capsid lattice with lenacapavir, showing how it disrupts capsid formation and function during virion maturation.
Nature Communications · Sep 22, 2026Peer-reviewedMicrobiology