NeurosciencebioRxivPreprint
(2R,6R)-hydroxynorketamine facilitates extinction and prevents emotional impairment and stress-induced reinstatement in morphine abstinent mice
Andria Michael, Anna Onisiforou, Polymnia Georgiou…·Panos Zanos
This paper demonstrates that (2R,6R)-hydroxynorketamine reverses maladaptive behaviors and prevents relapse in morphine-abstinent mice by enhancing BDNF and GluN2A signaling.
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