Morfeas Koumas

Selective transcriptomic recovery by (2R,6R)-hydroxynorketamine in opioid-abstinent mice: Machine learning identifies predictive biomarkers

This study uses machine learning to identify predictive biomarkers of (2R,6R)-HNK treatment response in opioid-abstinent mice, revealing gene expression changes and context-dependent therapeutic effects.

(2R,6R)-hydroxynorketamine facilitates extinction and prevents emotional impairment and stress-induced reinstatement in morphine abstinent mice

This paper demonstrates that (2R,6R)-hydroxynorketamine reverses maladaptive behaviors and prevents relapse in morphine-abstinent mice by enhancing BDNF and GluN2A signaling.