Yan Guo

A modular architecture of human cellular aging across organs and diseases

This study identifies modular patterns of cellular aging across organs and diseases using single-cell transcriptomics and proteomics, revealing conserved and organ-specific aging programs.

Comprehensive profiling of transcriptional regulation in cartilage reveals pathogenesis of osteoarthritis

The paper identifies eQTLs and regulatory mechanisms in cartilage to uncover potential mechanisms of osteoarthritis pathogenesis.

Mendelian Randomization analyses identify causal associations of human gut microbiome composition on intelligence

The paper uses Mendelian randomization to find causal links between gut microbiome taxa and intelligence, identifying Oxalobacter as a risk factor and Fusicatenibacter as protective.

Evaluation of the causal associations between brain imaging-derived phenotypes and type 2 diabetes: a bidirectional Mendelian randomization study

This study uses Mendelian randomization to examine causal links between brain imaging phenotypes and type 2 diabetes traits, finding bidirectional associations.

Novel Roles of G-quadruplexes on Enhancers in human chromatin

This study identifies G-quadruplexes on enhancers as regulators of chromatin structure and enhancer activity by promoting nucleosome depletion and TF recruitment.

Phenome-wide investigation of the causal associations between childhood BMI and adult outcomes: A two-sample Mendelian randomization study

This study uses Mendelian randomization to investigate causal associations between childhood BMI and 60 adult traits, finding adverse effects on health and disease risk, but also positive associations with certain lifestyle factors.

Brain image-derived phenotypes yield insights into causal risk of psychiatric disorders using a Mendelian randomization study

This study uses Mendelian randomization to identify causal relationships between brain imaging phenotypes and psychiatric disorders, finding 17 forward and 14 reverse causal associations.

LDBlockShow: a fast and convenient tool for visualizing linkage disequilibrium and haplotype blocks based on variant call format files

LDBlockShow visualizes linkage disequilibrium and haplotype blocks from VCF files efficiently, outperforming existing tools in speed and memory usage.

3D chromatin organization changes modulate adipogenesis and osteogenesis

The paper identifies changes in chromatin loops during adipogenesis and osteogenesis in hMSCs and links them to gene activation and cell fate determination.

An allele-specific functional SNP associated with two autoimmune diseases modulates IRF5 expression by long-range chromatin loop formation

The paper identifies a functional SNP associated with SLE and SSc that regulates IRF5 expression through long-range chromatin looping.

Modeling circRNAs expression pattern with integrated sequence and epigenetic features identifies H3K79me2 as regulators for circRNAs expression

The paper introduces CIRCScan, a machine learning framework that predicts circRNA expression using sequence and epigenetic features, identifying H3K79me2 as a key regulator.