Jing Guo

This study identifies modular patterns of cellular aging across organs and diseases using single-cell transcriptomics and proteomics, revealing conserved and organ-specific aging programs.

TN-783, a CNS-penetrant NLRP3 inhibitor, induces sustained weight loss and reverses hypothalamic inflammation in diet-induced obese mice.

The paper uses Mendelian randomization to find causal links between gut microbiome taxa and intelligence, identifying Oxalobacter as a risk factor and Fusicatenibacter as protective.

This study uses Mendelian randomization to examine causal links between brain imaging phenotypes and type 2 diabetes traits, finding bidirectional associations.

This study uses Mendelian randomization to identify causal relationships between brain imaging phenotypes and psychiatric disorders, finding 17 forward and 14 reverse causal associations.

The paper identifies changes in chromatin loops during adipogenesis and osteogenesis in hMSCs and links them to gene activation and cell fate determination.