Fuling Zhou

This study creates novel hybrid aminoglycoside antibiotics by swapping glycosyltransferases between gentamicin and kanamycin producers, resulting in compounds with potent activity and reduced ototoxicity.

This study introduces MGA-Seq, a method to detect multiple genomic abnormalities, and finds that focal amplification in tumors is heterogeneous and reveals ecDNA network architecture.

The paper introduces CIRCScan, a machine learning framework that predicts circRNA expression using sequence and epigenetic features, identifying H3K79me2 as a key regulator.