Wei Shi

A modular architecture of human cellular aging across organs and diseases

This study identifies modular patterns of cellular aging across organs and diseases using single-cell transcriptomics and proteomics, revealing conserved and organ-specific aging programs.

Improve the Efficacy of B7-H3-Targeting Antibody-Drug Conjugate DS-7300a in TP53-deficient Tumors by Inducing Ferroptosis

This study shows that TP53-deficient tumors resist DS-7300a therapy, but inducing ferroptosis can enhance its efficacy in these cancers.

HuiduRep: A Robust Self-Supervised Framework for Learning Neural Representations from Extracellular Recordings

HuiduRep is a self-supervised framework that learns robust representations from extracellular recordings, improving spike sorting performance across datasets and outperforming existing tools.

Pan-cancer N-glycoproteomic atlas of patient derived xenografts uncovers FAT2 as a therapeutic target for head and neck cancers

This paper uses N-glycoproteomics to analyze patient-derived xenografts, identifies FAT2 as a therapeutic target for head and neck cancers, and validates its role in tumor growth and CAR T cell activity.

Dark-based Optical Sectioning assists Background Removal in Fluorescence Microscopy

This paper introduces a method to remove defocus backgrounds in fluorescence microscopy using dark channels and dual frequency separation, significantly improving image quality.

A high-throughput analysis method of microdroplet PCR coupled with fluorescence spectrophotometry

This paper introduces a microdroplet PCR method combined with fluorescence spectrophotometry for qualitative, quantitative, and high-throughput DNA detection, validated using GM maize and foodborne bacteria.