Hao Chen

The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway

This study shows that USP7 deletion in mice causes neurological phenotypes, including synaptic proteome changes and dendritic spine defects, independent of p53.

α-synucleinopathy associated calcium overload and autophagy failure is regulated by gain-of-function of Tousled-like kinase

The paper identifies TLK2 as a key regulator of calcium overload-induced mitochondrial and autophagy dysfunction in Parkinson's disease using Drosophila and mammalian models.

3D chromatin organization changes modulate adipogenesis and osteogenesis

The paper identifies changes in chromatin loops during adipogenesis and osteogenesis in hMSCs and links them to gene activation and cell fate determination.

Gallic Acid Disrupts Aβ1-42 Aggregation and Rescues Cognitive Decline of APP/PS1 Transgenic Mouse

This study shows that gallic acid reduces Aβ1-42 aggregation and neurotoxicity, improving cognitive decline in APP/PS1 transgenic mice.