Author

Patrick J. Casey

Duke Medical CenterORCID 0000-0002-7366-9309Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Mei WangiD· 2 shared Dalton N. HughesiD· 1 shared Kafui DzirasaiD· 1 shared Okechi Boms· 1 shared Rainbo C. HultmaniD· 1 shared Stephen D. Mague· 1 shared Subbulakshmi KarthikeyaniD· 1 shared Victor Nadler· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

Mei WangORCID

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3 papers

Recent·Most cited

WNT11 suppresses tumor initiation and invasion by inactivating RAC1

Subbulakshmi Karthikeyan, Patrick J. Casey, Mei Wang

This study shows WNT11 suppresses tumor initiation and invasion by inhibiting RAC1 activation in human epithelial cancer models.

bioRxiv · Jul 15, 2026 · PreprintCancer Biology

Concurrent inhibition of ICMT and RAF/MEK suppresses RAC1P29S-driven MAPKi resistance in BRAFV600E melanoma by regulating TAZ activity

Xiaoyang Gu, Patrick J. Casey, Mei Wang

This study shows that combining ICMT and MAPK inhibitors suppresses RAC1P29S-driven resistance in BRAFV600E melanoma by inhibiting TAZ activity.

bioRxiv · Aug 10, 2025 · PreprintCancer Biology

A Role for Gαz in regulating seizure susceptibility

Rainbo C. Hultman, Okechi Boms, Stephen D. Mague, Dalton N. Hughes, Victor Nadler, Kafui Dzirasa, Patrick J. Casey

This study investigates the role of Gαz in seizure susceptibility by analyzing Gz-null mice and finding increased seizure susceptibility and electrographic seizure activity.

bioRxiv · Mar 6, 2019 · PreprintNeuroscience