Stephen D. Mague

A widespread internal brain state for fentanyl withdrawal

A multisite LFP network (EN-Withdrawal), found with supervised dCSFA-NMF in fentanyl-withdrawing mice, classifies morphine withdrawal, tracks behavioral severity, and its rise predicts fentanyl self-administration escalation in experienced mice.

Long-term editing of brain circuits in mice using an engineered electrical synapse

The paper engineers an electrical synapse in mice using fish connexins to modulate neural circuits and behavior.

Sleep-wake states are encoded across emotion-regulation regions of the mouse brain

The paper examines how brain regions involved in emotion regulation encode sleep-wake states in mice using electrophysiological recordings and develops classifiers to distinguish sleep states from neural activity.

An electrical brain network encodes anxiety in health and depressive states

The paper identifies a multi-region brain network that encodes anxiety in healthy and depressive states using electrical recordings and machine learning in mice.

Prenatal Environmental Stressors Impair Postnatal Microglia Function and Adult Behavior in Males

This study shows that prenatal exposure to environmental toxins and stress impairs microglial function and leads to behavioral issues in male mice.

Long-term precision editing of neural circuits in mammals using engineered gap junction hemichannels

The paper develops engineered gap junction hemichannels to enable precise, long-term neural circuit editing in mammals by enabling communication between distinct cell types.

Brain-wide electrical dynamics encode an appetitive socioemotional state

The paper identifies a brain network encoding socioemotional behavior using machine learning on electrical activity from mice during social interactions.

Brain-wide electrical spatiotemporal dynamics encode reward anticipation

The paper identifies a brain network encoding reward anticipation through multi-region electrical recordings and machine learning analysis in mice.

A Role for Gαz in regulating seizure susceptibility

This study investigates the role of Gαz in seizure susceptibility by analyzing Gz-null mice and finding increased seizure susceptibility and electrographic seizure activity.

A convergent depression vulnerability pathway encoded by emergent spatiotemporal dynamics

The paper identifies a spatiotemporal dynamic network in the brain associated with depression vulnerability using machine learning and LFP data from stressed mice.