Author

Lawrence Clarke Layman

Augusta UniversityORCID 0000-0002-7369-9575Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Paris AtaliotisiD· 2 shared Yeon-Joo KimiD· 2 shared Cheol-Hee Kim· 1 shared Dae‐Won KimiD· 1 shared Daniel P. S. OsborniD· 1 shared Dorothy C. BennettiD· 1 shared Francesc MirallesiD· 1 shared Hyun–Taek Kim· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Paris AtaliotisORCID

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2 papers

Recent·Most cited

Loss of Kallmann syndrome-associated gene WDR11 disrupts primordial germ cell development by affecting canonical and non-canonical Hedgehog signalling

Ji‐Young Lee, Yeon-Joo Kim, Paris Ataliotis, Hyung‐Goo Kim, Dae‐Won Kim, Dorothy C. Bennett, Nigel Andrew Brown, Lawrence Clarke Layman, Soo‐Hyun Kim

This study shows that WDR11 loss disrupts primordial germ cell development by impairing both canonical and non-canonical Hedgehog signaling pathways.

bioRxiv · Sep 6, 2020 · PreprintGenetics

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome

Yeon-Joo Kim, Daniel P. S. Osborn, Ji‐Young Lee, Masatake Araki, Kimi Araki, Timothy J. Mohun, Johanna Känsäkoski, Nina Brandstack, Hyun–Taek Kim, Francesc Miralles, Cheol-Hee Kim, Nigel A. Brown, Hyung-Goo Kim, Juan Pedro Martinez-Barbera, Paris Ataliotis, , Soo-Hyun Kim

This study identifies WDR11 as a regulator of Hedgehog signaling and ciliogenesis, linking its mutations to ciliopathy and Kallmann syndrome.

EMBO Reports · Dec 20, 2017Peer-reviewedDevelopmental Biology