Chalcogen derivatives for the treatment of African trypanosomiasis: biological evaluation of thio and seleno- semicarbazones and their azole derivatives
Mercedes Rubio-Hernández, Thaiz R. Teixeira, Tina P. Nguyen, Mai Shingyoji, Elany Barbosa da Silva, Anthony John O’Donoghue, Conor R. Caffrey, Silvia Pérez‐Silanes, Nuria Martínez‐Sáez
The paper evaluates thio- and seleno-semicarbazones and their azole derivatives for treating African trypanosomiasis, finding Se derivatives more active than S analogues and highlighting the importance of combining TbrCATL inhibition with antioxidant activity.
ACS Omega · Jun 5, 2025Peer-reviewedMicrobiology