Conor R. Caffrey

This paper identifies a new class of thiophen-2-yl pyrimidines (TPPs) with improved solubility and potency against Schistosoma species, suggesting novel targets beyond tubulin.

The paper screens two small-molecule libraries for anthelmintic compounds using a C. elegans motility assay, identifying three novel compounds with varying toxicity.

The paper demonstrates the use of photoaffinity labeling in Schistosoma mansoni to identify protein-ligand interactions, showing specific tubulin labeling and potential for drug target discovery.

The paper evaluates thio- and seleno-semicarbazones and their azole derivatives for treating African trypanosomiasis, finding Se derivatives more active than S analogues and highlighting the importance of combining TbrCATL inhibition with antioxidant activity.

The paper develops subunit-specific proteasome substrates for Schistosoma species, showing improved performance and cross-species applicability.

This study identifies cysteine proteases in Necator americanus as potential virulence factors and explores their interaction with heparin for drug design against hookworm infection.