Glycation modulates glutamatergic signalling and exacerbates Parkinson's disease-like phenotypes
Ana Chegão, Mariana Guarda, Bruno M. Alexandre, Liana Shvachiy, Mariana Temido‐Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa Vaqueiro Lopes, Pedro R. Florindo, Ricardo A. Gomes, Patrícia Gomes‐Alves, Joana Esteves Coelho, Tiago F. Outeiro, Hugo Vicente Miranda
This study shows that glycation worsens Parkinson's-like symptoms in mice by enhancing glutamatergic signaling and causing dopaminergic neuron loss.
bioRxiv · Aug 24, 2021 · PreprintNeuroscience