Rune Matthiesen

This study defines the core proteome and contaminants of plasma extracellular vesicles through a meta-analysis of 515 human proteomes, revealing distinct biological sources and functional modules.

EV-Net is a computational tool that adapts NicheNet to analyze EV cargo effects on recipient tissues, enabling prioritization of regulatory molecules from proteomics and RNA-seq data.

This study shows that lactate-derived histone lactylation increases during zebrafish caudal fin regeneration, linking metabolic changes to epigenetic regulation of tissue repair.

This study shows that glycation worsens Parkinson's-like symptoms in mice by enhancing glutamatergic signaling and causing dopaminergic neuron loss.