Author

Hugo Vicente Miranda

Universidade Nova de LisboaORCID 0000-0001-8065-9259Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ana ChegãoiD· 3 shared Tiago F. OuteiroiD· 3 shared Bárbara Fernandes GomesiD· 2 shared Annekatrin König· 1 shared Bruno M. AlexandreiD· 1 shared Clara Bosbach· 1 shared Claudia SteinemiD· 1 shared Daniel ErskineiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersNeuroscience

Ana ChegãoORCID

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3 papers

Recent·Most cited

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses

Eftychia Vasili, Annekatrin König, Mohammed Al‐Azzani, Clara Bosbach, Luisa Maria Gatzemeier, Searlait Thom, Ana Chegão, Hugo Vicente Miranda, Claudia Steinem, Daniel Erskine, Tiago F. Outeiro

This study shows that glycation of alpha-synuclein increases its aggregation and neuroinflammatory responses, linking type 2 diabetes and Parkinson's disease.

npj Parkinson s Disease · Oct 23, 2025Peer-reviewedNeuroscience

Glycation modulates glutamatergic signalling and exacerbates Parkinson's disease-like phenotypes

Ana Chegão, Mariana Guarda, Bruno M. Alexandre, Liana Shvachiy, Mariana Temido‐Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa Vaqueiro Lopes, Pedro R. Florindo, Ricardo A. Gomes, Patrícia Gomes‐Alves, Joana Esteves Coelho, Tiago F. Outeiro, Hugo Vicente Miranda

This study shows that glycation worsens Parkinson's-like symptoms in mice by enhancing glutamatergic signaling and causing dopaminergic neuron loss.

bioRxiv · Aug 24, 2021 · PreprintNeuroscience

Hsp27 reduces glycation-induced toxicity and aggregation of α-synuclein

Hugo Vicente Miranda, Ana Chegão, Márcia Santos Duarte de Oliveira, Bárbara Fernandes Gomes, Francisco J. Enguita, Tiago F. Outeiro

This study shows that Hsp27 reduces glycation-induced toxicity and aggregation of α-synuclein in cellular models.

The FASEB Journal · Apr 7, 2020Peer-reviewedNeuroscience