Staging Alzheimer’s disease in the brain and retina of B6.APP/PS1 mice by transcriptional profiling
Sumana R. Chintapaludi, Asli Uyar, Harriet M. Jackson, Casey J. Acklin, Xulong Wang, Michael Sasner, Gregory W. Carter, Gareth R. Howell
The paper uses RNA sequencing and GLM to analyze molecular changes in B6.APP/PS1 mice brains and retinas, identifying JAK/STAT pathway activation and suggesting limited translatability of retinal changes to human AD.
Journal of Alzheimer s Disease · Jan 9, 2020Peer-reviewedNeuroscience