Michael Sasner

The paper characterizes the AppSAA knock-in mouse model, showing it recapitulates age-dependent Alzheimer's disease phenotypes and provides a tool for preclinical research.

The paper shows that the MTHFR*677C>T variant in a mouse model of LOAD produces distinct transcriptional and proteomic signatures related to cerebrovascular and synaptic biology.

This study examines the molecular effects of aducanumab treatment in 5XFAD mice, revealing sex-dependent and IgG-mediated changes in amyloid and associated pathways.

This study shows that human KL haplotypes FC and VS cause widespread transcriptomic changes in mouse brains at 12 months old, affecting mitochondrial, ribosomal, and synaptic functions, and linking them to Alzheimer's Disease pathogenesis.

This study compares two mouse models of TREM2 variants, showing both mimic Alzheimer's disease signatures in similar biological domains.

This paper characterizes cerebrovascular phenotypes in WSB.APP/PS1 mice, showing age-related CAA, transcriptomic overlap with human AD, myelin deficits, and APOE allele-dependent effects on vascular pathology.

The paper identifies neuronal proteins that degrade slower with aging and accumulate in microglia, linking impaired synaptic protein turnover to age-related cognitive decline.

This study characterizes molecular and synaptic changes in a mouse model of late-onset Alzheimer's disease under different dietary conditions, showing age-related brain volume loss and cognitive deficits.

The paper functionally validates 11 genetic risk variants for late-onset Alzheimer's disease using a mouse model and compares transcriptomic effects to human cohorts.

The paper identifies sex-specific metabolomic differences in serum and brain of Alzheimer's disease mouse models, showing model-specific metabolic signatures that align with human APOE4 carriers.

This study creates a mouse model with the MTHFR 677C>T variant and shows it causes cerebrovascular deficits, supporting its use in preclinical research on vascular dementia.

This study shows that a high fat-high sugar diet interacts with the Plcg2M28L genetic variant to accelerate Alzheimer's disease-like phenotypes in mice.

This study identifies SPP1 as a key mediator of microglial synaptic engulfment in Alzheimer's disease models, showing its role in neuroimmune interactions.

This study shows that APOEϵ4 genotype interacts with exercise to influence systemic and cerebral risk factors for dementia in mice, with sex-specific effects on metabolism, brain function, and aging.

This paper characterizes microglial metabolic changes in an APP knock-in mouse model of AD, finding lipid dysregulation and immunometabolic perturbations linked to fibrillar Aβ.

The paper introduces a NanoString nCounter Mouse AD panel to assess LOAD mouse models by correlating gene expression with human AD modules, showing strong correlation with RNA-Seq data.

This study identifies unique gene signatures in the cortex of young mice with APOEε3/ε4 and APOEε4/ε4 genotypes, showing distinct transcriptomic and functional differences.

This paper identifies a protective PLCG2 variant in Alzheimer's disease, showing enhanced PLCγ2 activation and functional changes in immune cells.

The paper uses RNA sequencing and GLM to analyze molecular changes in B6.APP/PS1 mice brains and retinas, identifying JAK/STAT pathway activation and suggesting limited translatability of retinal changes to human AD.

This study identifies insertion sites in 40 transgenic mouse lines, revealing frequent disruptions of endogenous genes and structural variations.