Asli Uyar

Single-subject Proteomic Signatures in Alzheimers Disease Reflect Clinical Phenotypes and Distinguish Asymptomatic from Symptomatic Cases

The paper introduces INDIGO, a framework for individual-level proteomic analysis in Alzheimer's Disease, identifying molecular subgroups linked to clinical and pathological features.

WSB.APP/PS1 mice develop age-dependent cerebral amyloid angiopathy, cerebrovascular dysfunction, and white matter deficits

This paper characterizes cerebrovascular phenotypes in WSB.APP/PS1 mice, showing age-related CAA, transcriptomic overlap with human AD, myelin deficits, and APOE allele-dependent effects on vascular pathology.

In vivo validation of late-onset Alzheimer's disease genetic risk factors

The paper functionally validates 11 genetic risk variants for late-onset Alzheimer's disease using a mouse model and compares transcriptomic effects to human cohorts.

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

The paper introduces a NanoString nCounter Mouse AD panel to assess LOAD mouse models by correlating gene expression with human AD modules, showing strong correlation with RNA-Seq data.

Staging Alzheimer’s disease in the brain and retina of B6.APP/PS1 mice by transcriptional profiling

The paper uses RNA sequencing and GLM to analyze molecular changes in B6.APP/PS1 mice brains and retinas, identifying JAK/STAT pathway activation and suggesting limited translatability of retinal changes to human AD.

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

The paper uses genetic mouse models to identify transcriptomic signatures of late-onset Alzheimer’s disease by comparing mouse gene modules with human brain modules.