C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent accumulation of Staufen in nucleus
Eun Seon Kim, Chang Geon Chung, Jeong Hyang Park, Byung Su Ko, Sung Soon Park, Yoon Ha Kim, In Jun Cha, Jaekwang Kim, Chang Man Ha, Hyung‐Jun Kim, Sung Bae Lee
The paper shows that Staufen accumulates in the nucleus in a C9orf72-associated Drosophila model and that reducing Staufen dosage mitigates PR toxicity.
Human Molecular Genetics · Mar 25, 2021Peer-reviewedGenetics