Tamás Mészáros

Combining AlphaFold 3 with microscale thermophoresis for aptamer optimisation

The paper combines AlphaFold 3 with microscale thermophoresis to study aptamer-protein interactions, finding that structural predictions are not reliable predictors of binding strength.

Acute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation

Hemoperfusion of pigs with a carbon-cellulose cartridge: a pilot study revealing a new animal model of extended anaphylactic shock

This study uses a porcine model to investigate anaphylactoid reactions caused by a carbon-cellulose cartridge, revealing mechanisms of cardiovascular collapse and shock.

Selection of streptococcal glucan-binding protein C specific DNA aptamers to inhibit biofilm formation

This study selects DNA aptamers targeting Streptococcus mutans GbpC to inhibit biofilm formation, showing 30% reduction in wild-type strains and no effect on GbpC-deficient strains.

LIFERING, an E3 ligase ubiquitinates the acyl-CoA dehydrogenase-like protein IBR3, and coordinates cell proliferation and death upon DNA damage

This study identifies LIFERING as an E3 ligase that ubiquitinates IBR3, linking DNA damage response to auxin regulation in plant roots.

Tryptophan-like side chain holding aptamers inhibit respiratory syncytial virus infection of lung epithelial cells

This study identifies aptamers that inhibit RSV infection by targeting the prefusion F protein, with modified nucleotides improving their stability and efficacy.