Luigi Zecca

Multiomic profiling reveals aberrant immunomodulatory signature in β-propeller protein-associated neurodegeneration patient iPSC-derived microglia

The paper uses iPSC-derived microglia from BPAN patients to identify immune-related alterations and immunomodulatory signaling changes, revealing a shift to a reactive, disease-associated state.

Synthetic neuromelanin as a trigger of inflammation in the brain, new mouse model of Parkinson's disease

This study shows that synthetic neuromelanin induces inflammation and may contribute to dopaminergic neuron degeneration in a new mouse model of Parkinson's disease.

Age-Associated Insolubility of Parkin in Human Midbrain is Linked to Redox Balance and Sequestration of Reactive Dopamine Metabolites

This study investigates how parkin's redox state and insolubility in human midbrain relate to oxidative stress and dopamine metabolism, showing that parkin's cysteine modifications affect H2O2 levels and neuroprotection.

Parkinson Disease-Linked Parkin Mediates Redox Reactions That Lower Oxidative Stress In Mammalian Brain

This study shows that parkin reduces oxidative stress in mammalian brains by mediating H2O2 reduction and glutathione regeneration, but its absence leads to increased oxidative stress despite compensatory mechanisms.