Author

Conan J O O’Brien

Translational Research InstituteORCID 0000-0002-7419-4448Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Immunology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

David Arthur HumeiD· 2 shared Emma L. MaxwelliD· 2 shared Ginell N. RanpuraiD· 2 shared Isis Taylor· 2 shared Katharine M. IrvineiD· 2 shared Sahar KeshvariiD· 2 shared Sébastien JacqueliniD· 2 shared Yajun LiuiD· 2 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

David Arthur HumeORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

ImmunologyDevelopmentPeer-reviewedJun 26, 2026

Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus.

Yajun Liu, Sébastien Jacquelin, Isis Taylor…·David Arthur Hume

This study shows that mice with a germ-line deletion of a Csf1r enhancer lack specific macrophages but maintain normal physiology and can be replenished by donor cells.

1 citation

mousebulk RNA-seq

𝕏 PostBluesky

ImmunologyJournal of Leukocyte BiologyPeer-reviewedJun 1, 2026

Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages

Sébastien Jacquelin, Emma L. Maxwell, Isis Taylor…·Katharine M. Irvine

This study shows that CSF1R-dependent macrophages are essential for hematopoiesis but many functions of tissue resident macrophages are redundant or strain-specific in mice.

4 citationstop 4%

mousebulk RNA-seq

𝕏 PostBluesky