Overexpression of GITRL by B cell IgD low (BDL) B cells is a therapeutic strategy to increase endogenous CD4+Foxp3+ T regulatory cells for the treatment of autoimmunity
M. I. Khalil, Cody J. Gurski, Robert Burns, Ryan Zander, Kelli C Sommers, Angela K. Beltrame, Bonnie N. Dittel
This study shows overexpressing GITRL on BDL B cells increases Treg numbers and reduces EAE severity in mice, suggesting a therapeutic strategy for autoimmunity.
bioRxiv · Feb 4, 2025 · PreprintImmunology