ImmunologybioRxivPreprint
Overexpression of GITRL by B cell IgD low (BDL) B cells is a therapeutic strategy to increase endogenous CD4+Foxp3+ T regulatory cells for the treatment of autoimmunity
M. I. Khalil, Cody J. Gurski, Robert Burns…·Bonnie N. Dittel
This study shows overexpressing GITRL on BDL B cells increases Treg numbers and reduces EAE severity in mice, suggesting a therapeutic strategy for autoimmunity.
DOI 10.1101/2025.02.04.636512