NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Daniel V. Oliveira, Kirsten Coupland, Wenchao Shao, Shaobo Jin, Francesca Del Gaudio, Sailan Wang, Rhys Fox, Julie W. Rutten, Johan Sandin, Henrik Zetterberg, Johan Lundkvist, Saskia A.J. Lesnik Oberstein, Urban Lendahl, Helena Karlström
This study shows active immunotherapy reduces NOTCH3 deposition in brain capillaries of CADASIL mice, with no adverse effects on behavior or vascular cells.
EMBO Molecular Medicine · Dec 16, 2022Peer-reviewedNeuroscience