Antony M Jose

The paper identifies two SID-1-dependent genes in C. elegans that influence reproduction and show transgenerational effects when altered.

The paper shows that dsRNA in C. elegans can be transmitted across generations and influence heritable gene expression through SID-1-mediated transport and retrotransposon regulation.

This paper develops a novel assay for measuring odorant responses in C. elegans without immobilization and finds variable associative learning in response to butanone.

The paper uses RNA silencing in C. elegans to prioritize understudied genes by clustering them based on mutual information derived from their functional relatedness and historical research trends, suggesting regulatory links between RNA silencing and other biological processes.

The paper shows that RNA interference selectivity in C. elegans arises from gene-specific RNA metabolism and restricted amplification, not specialized pathways.

The paper shows that heritable RNA silencing in C. elegans can occur through multiple distinct mechanisms, each detectable by unique mRNA fragment signatures.

The paper develops criteria for heritability of regulatory architectures and shows how they influence epigenetic changes through simulations and analysis of C. elegans RNA silencing.

The paper shows that gene-specific homeostasis in C. elegans enables recovery from transgenerational RNA silencing, with silencing persisting for over 250 generations under certain conditions.

The paper shows that gene silencing via dsRNA in C. elegans neurons can occur in intestinal cells lacking RRF-1, requiring EGO-1 and revealing functional mosaicism.

The paper discusses the dual information stores in cells - replicating DNA and cycling molecular arrangements - and their coevolution in perpetuating life.

The paper shows that long dsRNA binding by RDE-4 is required for systemic RNAi in C. elegans, contradicting previous findings using repetitive transgenes.