Douglas W. Houston

The paper develops and validates novel monoclonal antibodies targeting the C-terminal HEAT domain of huntingtin, showing they detect full-length HTT regardless of polyglutamine length or HAP40 interaction.

This study shows that rabbit kappa light chain allotypes affect chimeric antibody expression and function, with K1-b9 maintaining robust performance due to a stable disulfide bond.

This paper introduces a commute time kernel for trajectory inference in single-cell data, showing it can replicate results from other methods across datasets and identify circadian-cycling progenitor cells.

This study identifies a maternal-effect mutation in Xenopus wnt11b and shows it affects cortical rotation and axis formation without involving Wnt coreceptors or Dishevelled.