Kelsey Coppenrath

Synapse specific alterations of autophagy are a hallmark of Danon disease

This study identifies synapse-specific autophagy alterations in Danon disease using a Xenopus tropicalis model, linking them to visual and cognitive impairments.

ADAM interact with large protein complexes to regulate Histone modification, gene expression and splicing.

The paper shows Adam13 regulates histone modifications, gene expression, and splicing in cranial neural crest cells by interacting with Arid3a and other proteins.

Sf3b4 mutation in Xenopus tropicalis causes RNA splicing defects followed by massive gene dysregulation that disrupt cranial neural crest development

This study shows that homozygous sf3b4 deletion in Xenopus tropicalis causes splicing defects and gene dysregulation, disrupting cranial neural crest development and leading to Nager syndrome-like features.

Maternal Wnt11b regulates cortical rotation during Xenopus axis formation: analysis of maternal-effect wnt11b mutants

This study identifies a maternal-effect mutation in Xenopus wnt11b and shows it affects cortical rotation and axis formation without involving Wnt coreceptors or Dishevelled.

Generation of a new six1-null line in Xenopus tropicalis for study of development and congenital disease

This paper generates a six1-null line in Xenopus tropicalis using CRISPR/Cas9 to study development and congenital disease.