Effects of NT5C2 germline variants on 6-mecaptopurine metabolism in children with acute lymphoblastic leukemia
Chuang Jiang, Wenjian Yang, Takaya Moriyama, Chengcheng Liu, Colton J. Smith, Wentao Yang, Maoxiang Qian, Ziping Li, Morten Tulstrup, Kjeld Schmiegelow, Kristine R. Crews, Hui Zhang, Ching‐Hon Pui, William Edward Evans, Mary V. Relling, , Jun J.J. Yang
This study identifies NT5C2 germline variants affecting 6-MP metabolism in ALL patients, showing two independent variants influence TGN levels.
Clinical Pharmacology & Therapeutics · Oct 29, 2020Peer-reviewedGenetics