Author

Deborah L. Burkhart

Harvard UniversityORCID 0000-0002-7457-6032Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Beatriz GermaniD· 2 shared Himisha BeltraniD· 2 shared Katherine L. MoreliD· 2 shared Leigh EllisiD· 2 shared Anjali Sheahan· 1 shared Ayesha A. ShafiiD· 1 shared Christopher J. SweeneyiD· 1 shared David P. LabbéiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Beatriz GermanORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 7, 2025

EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer

Beatriz German, Katherine L. Morel, Teia Noel…·Leigh Ellis

This paper identifies the EZH2-TTP-mTORC1 axis as a driver of phenotypic plasticity and therapeutic vulnerability in prostate cancer, showing that combined inhibition of EZH2 and PI3K/mTORC1 improves anti-tumor activity.

1 citation

mouseexperimental assay

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Cancer BiologybioRxivPreprintJan 31, 2024

MYBL2 drives prostate cancer plasticity and identifies CDK2 as a therapeutic vulnerability in RB1-loss and neuroendocrine prostate cancer

Beatriz German, Jagpreet N. Singh, Marcos AdS Fonseca…·Leigh Ellis

This study identifies MYBL2 as a master regulator of phenotypic plasticity in prostate cancer and shows CDK2 inhibition as a potential therapeutic strategy for MYBL2-driven tumors.

DOI 10.1101/2024.01.31.578216

mousebulk RNA-seq

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