Cold acclimation reprograms hepatic lipid composition toward n-3 HUFAs to uncouple adipose-derived lipid flux from steatosis
Victor Azevêdo Vieira, Gabriel Salerno Costa, Gabriela Segura Gonzales, Raphael Campos Guimarães, Cristiane dos Santos, Raul Gobato da Costa, Marcella Ramos Sant'Ana, Camila de Oliveira Ramos, Murilo Henrique Anzolini Cassiano, João Manoel Alves, Nayara Fernanda Pereira, Paulo Henrique Melo, Tiago Tomazini Gonçalves, Isabella Bonilha, Caio Fábio Baeta Lopes, , Luiz Osório Leiria
The paper shows cold acclimation increases n-3 HUFAs in the liver, reducing steatosis by altering lipid composition and metabolism.
bioRxiv · Mar 31, 2026 · PreprintBiochemistry