CRISPR-mediated centromere fission generates neo-chromosomes with distorted meiotic inheritance in Arabidopsis
Robin Burns, Terezie M. Mandáková, Chris Morgan, Stephanie D. Topp, Nicola Gorringe, Tong Li, Katharine M. Jenike, Piotr Włodzimierz, Matthew Naish, Martin A. Lysák, Ian R. Henderson
This study uses CRISPR to reposition centromeres in Arabidopsis, showing how neo-chromosomes with altered centromere positions lead to meiotic segregation distortion and aneuploidy.
bioRxiv · Jul 24, 2026 · PreprintGenetics