Martin Howard

The paper investigates cold-induced repression of FLC in Arabidopsis, finding distinct mechanisms involving splicing changes and reduced transcription initiation, separate from warm-induced repression.

The paper identifies Polycomb-regulated gene expression and chromatin state differences in iPSCs that correlate with differentiation efficiency.

The paper develops a computational model to explain how proximal termination influences the rate of Polycomb silencing establishment at the FLC locus in Arabidopsis.

The paper develops a mathematical model showing bidirectional feedback between chromatin compaction and histone modifications explains bistability in S. cerevisiae heterochromatin.

The paper develops a mathematical model to explain how DNA methylation patterns are established and inherited in Arabidopsis thaliana genes, showing they undergo long-term epigenetic fluctuations.

The paper shows that antisense transcription and PRC2 silencing work together to regulate FLC during vernalization, with different response dynamics influenced by temperature and growth conditions.

The paper shows that FLC gene expression in Arabidopsis is regulated by both analog and digital modes before cold exposure, with analog preceding digital and leading to gradual repression.

The paper develops a coarsening model to explain meiotic crossover patterning in Arabidopsis with and without the synaptonemal complex, showing it can reproduce experimental data and predict patterns in different genetic backgrounds.

The paper shows that de novo methylation stabilizes epigenetic inheritance of CG methylation in Arabidopsis transposons, counteracting maintenance failure.

The paper shows that natural variation in FLC levels and early silencing, not epigenetic silencing, determines vernalization response in Arabidopsis to different climates.