HIV-1 Amplifies IL-8 Response Of Human Stellate Cells To Gram-Positive Microbial Products Via H4K5 Histone Acetylation
Lumin Zhang, Rabab O. Ali, Naichaya Chamroonkul, Parissa Tabrizian, Myron Schwartz, Ganesh Gunasekaran, Thomas D. Schiano, Maria Isabel Fiel, Stephen Andrew Ward, Meena B. Bansal
This study shows HIV-1 enhances IL-8 production in HSCs in response to LTA through histone H4K5 acetylation, contributing to liver fibrosis in HIV-positive individuals.
bioRxiv · May 12, 2025 · PreprintImmunology