The paper identifies TREM2-expressing macrophages as predictors of response to PD-1 blockade in HCC patients using clinical and spatial transcriptomic data.

bioRxiv · Sep 9, 2025 · PreprintImmunology

HIV-1 Amplifies IL-8 Response Of Human Stellate Cells To Gram-Positive Microbial Products Via H4K5 Histone Acetylation

Lumin Zhang, Rabab O. Ali, Naichaya Chamroonkul, Parissa Tabrizian, Myron Schwartz, Ganesh Gunasekaran, Thomas D. Schiano, Maria Isabel Fiel, Stephen Andrew Ward, Meena B. Bansal

This study shows HIV-1 enhances IL-8 production in HSCs in response to LTA through histone H4K5 acetylation, contributing to liver fibrosis in HIV-positive individuals.

bioRxiv · May 12, 2025 · PreprintImmunology

MARQO pipeline resolves multiparametric cellular and spatial organization in cancer tissue lesions

Mark Buckup, Igor Figueiredo, Giorgio Ioannou, Sinem Ozbey, Rafael Cabal, Alexandra Tabachnikova, Leanna Troncoso, Jessica Le Bérichel, Zhen Zhao, Stephen C. Ward, Clotilde Hennequin, Güray Aktürk, Steven Hamel, Maria Isabel Fiel, Rachel Brody, , Sacha Gnjatic

MARQO pipeline automates single-cell analysis of multiplex immunostained tissue slides, showing improved accuracy over manual methods in cancer studies.

bioRxiv · Apr 24, 2025 · PreprintImmunology

NOTCH1 drives tumor plasticity and metastasis in hepatocellular carcinoma

Katherine E. Lindblad, Romain Donné, Ian Liebling, Erin R. Bresnahan, Marina Bárcena‐Varela, Anthony Lozano, Eric Y. H. Park, Bruno Giotti, Olivia K. Burn, Maria Isabel Fiel, Clara Alsinet, Satdarshan P. Monga, Ruidong Xue, Jose Javier Bravo‐Cordero, Alexander M. Tsankov, Amaia Lujambio

This paper develops a novel mouse model showing NOTCH1 drives temporal plasticity and metastasis in hepatocellular carcinoma through angiogenesis and TGFβ pathways.

bioRxiv · Oct 23, 2024 · PreprintCancer Biology