Christopher Butler

Cerebrospinal fluid YWHAG:NPTX2 ratio predicts clinical severity and future phenoconversion in frontotemporal lobar degeneration

The paper identifies the CSF YWHAG:NPTX2 ratio as a biomarker for predicting clinical severity and phenoconversion in FTLD, showing strong correlation with disease progression and improved trial design potential.

Machine-learning MRI stratification of genetic frontotemporal dementia for clinical trial enrichment

This paper uses machine learning to stratify genetic frontotemporal dementia patients into subtypes and provides progression scores that improve trial enrichment efficiency.

A spatially-specific pattern of cortical thickness in frontal lobe predisposes to faster future amyloid accumulation in individuals with subjective cognitive decline

The paper identifies a frontal lobe cortical thickness pattern in amyloid-negative individuals that predicts faster amyloid accumulation over five years.

Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation

This study demonstrates acoustoelectric neuromodulation as a mechanism for non-invasive brain stimulation, showing its contribution to ultrasound effects on neural activity.

Diencephalic integrity explains aspects of hippocampal amnesia

The paper shows that diencephalic nuclei and white matter integrity, not just hippocampal damage, explain aspects of hippocampal amnesia in patients with autoimmune limbic encephalitis.

MRI-based classifier to identify close-to-onset cases in C9orf72 genetic frontotemporal dementia

The paper develops an MRI-based machine learning classifier to identify presymptomatic C9orf72 carriers at high risk of disease onset within two years.

White Matter Hyperintensities Precede other Biomarkers in GRN Frontotemporal Dementia

The paper shows that white matter hyperintensities (WMHs) appear before other biomarkers in GRN-related frontotemporal dementia, suggesting they are early indicators of disease progression.

The link between gender inequality and the distribution of brain regions' relative sizes across the lifespan and the world

The paper examines how gender inequality affects brain grey matter differences between males and females across age and geography, finding a cumulative effect with age and economic factors dominating the influence.

Cerebellar and subcortical atrophy contribute to psychiatric symptoms in frontotemporal dementia

This study investigates the association between cerebellar and subcortical atrophy and neuropsychiatric symptoms in genetic frontotemporal dementia, finding significant differences across genetic mutations.

Global network structure and local transcriptomic vulnerability shape atrophy in sporadic and genetic behavioral variant frontotemporal dementia

This study shows that atrophy patterns in bvFTD are shaped by both global brain network structure and local transcriptomic vulnerability from disease-related genes.

Functional specialization of the medial temporal lobes in human recognition memory: dissociating effects of hippocampal vs parahippocampal damage.

This study examines the functional specialization of the medial temporal lobes in recognition memory by comparing the effects of hippocampal and parahippocampal damage in a patient with a perirhinal lesion.

Transcranial ultrasound stimulation in humans is associated with an auditory confound that can be effectively masked

This study shows that transcranial ultrasound stimulation (TUS) produces audible sounds in humans that can be masked by concurrent audio signals.

Analysis of brain atrophy and local gene expression in genetic frontotemporal dementia

The paper investigates the relationship between gene expression and brain atrophy in genetic frontotemporal dementia, finding correlations between atrophy patterns and specific gene sets related to vascular, glial, and neuronal functions.

Data-driven algorithm for the diagnosis of behavioral variant frontotemporal dementia

The paper develops a random forest classifier to diagnose behavioral variant frontotemporal dementia using MRI and cognitive scores, achieving high accuracy in both training and validation cohorts.

Network-wide abnormalities explain memory variability in hippocampal amnesia

The paper investigates memory variability in hippocampal amnesia by analyzing network-wide abnormalities in a cohort of patients with autoimmune limbic encephalitis.