Hamilton Se‐Hwee Oh

The paper compares three plasma proteomic metrics across organ systems to assess their associations with brain structure and neurodegenerative disease, finding distinct relationships and modest predictive value.

The paper identifies the CSF YWHAG:NPTX2 ratio as a biomarker for predicting clinical severity and phenoconversion in FTLD, showing strong correlation with disease progression and improved trial design potential.

This study identifies sex-specific changes in bone and senescence-related proteins in neurodegenerative diseases using plasma proteomics.

The paper identifies a plasma proteomic signature linked to blood-brain barrier dysfunction, which predicts cognitive decline after ischemic stroke.

The paper uses plasma proteomics to estimate biological age of multiple cell types and links aging signatures to disease risk and mortality across 60,000 individuals.

The paper investigates age-related changes in cerebellar microglia using single-nuclei RNA sequencing and MERFISH, finding enhanced neuroprotective immune activation and proximity to granule cells in aged mice.

The paper identifies neuronal proteins that degrade slower with aging and accumulate in microglia, linking impaired synaptic protein turnover to age-related cognitive decline.

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

The paper uses plasma proteomics from the UK Biobank to estimate organ age and links it to disease risk and longevity.

This study identifies four novel genetic loci associated with soluble TREM2 levels in CSF through GWAS and provides functional validation of their roles in Alzheimer's disease.