Sarosh R. Irani

Leucine-rich glioma inactivated 1 is a ganglioside-binding protein

The paper shows LGI1 binds gangliosides and may organize lipid platforms for ion channels, and its loss disrupts these platforms in mice.

Permissive central tolerance plus defective peripheral checkpoints licence pathogenic memory B cells in CASPR2-antibody encephalitis

Single CAR-Dual target: Intracranial Delivery of Anti-PD-L1 CAR T Cells Effectively Eradicates Glioma and Immunosuppressive Cells in the Tumor Microenvironment.

This study develops a PD-L1-targeting CAR T cell therapy, MC9999, which effectively eradicates glioblastoma and immunosuppressive cells in the tumor microenvironment through intracranial delivery.

Neurodegenerative fluid biomarkers are enriched in human cervical lymph nodes

This study detects neurodegenerative biomarkers in human cervical lymph nodes, showing higher concentrations than plasma and age-related changes in phospho-Tau-181.

LGI1 autoantibodies enhance synaptic transmission by presynaptic Kv1 loss and increased action potential broadening

This study investigates how LGI1 autoantibodies enhance synaptic transmission by reducing Kv1 channel density and broadening presynaptic action potentials.

Peripherally derived LGI1-reactive monoclonal antibodies cause epileptic seizures in vivo

This study shows that LGI1-reactive monoclonal antibodies cause seizures in rats, with molecular and electrophysiological evidence of epileptogenesis.

Patient-derived recombinant autoantibodies reveal the subcellular neuroglial distribution and heterogeneous interactome of leucine-rich glioma-inactivated 1

The paper uses patient-derived autoantibodies to study LGI1 localization and interactome in mouse brains, revealing its synaptic distribution and novel protein complexes.

An epitope specific patient-derived LGI1-autoantibody enhances neuronal excitability by modulating the Kv1.1 channel.

This study shows that an epitope-specific LGI1-autoantibody modulates Kv1.1 channel function, increasing neuronal excitability and potentially contributing to epileptiform activity.

Network-wide abnormalities explain memory variability in hippocampal amnesia

The paper investigates memory variability in hippocampal amnesia by analyzing network-wide abnormalities in a cohort of patients with autoimmune limbic encephalitis.