Anthony Sonn

Senescent fibroblasts interfere with the tumor immune response in humanized models by inducing neutrophil extracellular traps

This study shows senescent fibroblasts in humanized mouse models promote tumor progression by inducing neutrophil extracellular traps (NETs) that impair immune responses.

Senescent human fibroblasts have increased FasL expression and impair the tumor immune response

The paper shows senescent human fibroblasts increase FasL expression, leading to T and NK cell apoptosis and impaired tumor immune response in humanized models.

T cell mediated impairment of epithelial integrity in Crohn's disease

This study shows that T lymphocytes from Crohn's disease patients impair intestinal epithelial integrity through increased cytotoxicity and altered immune responses in a 3D coculture model.