Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and -independent mechanisms
Antonio Rodríguez-Blázquez, Arturo Carabias, Alba Morán-Vaquero, Sergio de Cima, Juan Román Luque-Ortega, Carlos Alfonso, Peter Schuck, José A. Manso, Sandra Macedo‐Ribeiro, Carmen Guerrero, José M. de Pereda
This study identifies two distinct mechanisms by which Crk proteins activate C3G: adaptor-dependent interactions with specific motifs and phosphorylation-dependent priming.
Cell Communication and Signaling · Feb 3, 2023Peer-reviewedMolecular Biology