Sandra Macedo‐Ribeiro

This study shows that CLR01, a supramolecular tweezer, reduces Atx3 aggregation by binding to a specific site, delaying fibril formation and improving symptoms in SCA3 models.

This study identifies dopamine and catecholamines as inhibitors of Atx3 aggregation, suggesting potential use of dopaminergic drugs for MJD treatment.

This study identifies two distinct mechanisms by which Crk proteins activate C3G: adaptor-dependent interactions with specific motifs and phosphorylation-dependent priming.

The paper identifies a conserved sequence and structural module in HtrA proteases, showing its repetition and association with beta-barrel domains across different protease clans.

The paper evaluates 43 methods for predicting intrinsically disordered regions and binding regions in proteins, finding that deep learning methods outperform older physicochemical approaches but binding prediction remains challenging.