Author

Gregory G. Cajka

Children's Hospital of PhiladelphiaORCID 0000-0002-7537-8310Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ophir ShalemiD· 2 shared Alyssa L. GagneiD· 1 shared Brianna Disanza· 1 shared Carolina Gracia-DiaziD· 1 shared Deborah L. FrenchiD· 1 shared Elizabeth J. K. BhojiD· 1 shared Ethan M. GoldbergiD· 1 shared Jean Ann Maguire· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Ophir ShalemORCID

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2 papers

Recent·Most cited

Cell BiologyCell SystemsPeer-reviewedSep 1, 2026

CRISPR associated enzymes are mislocalized to the cytoplasm in iPSC-derived neurons resulting in KRAB-specific degradation

Gregory G. Cajka, Nima N. Naseri, Matthew Liu, Ophir Shalem

This study identifies that dCas9-KRAB mislocalizes to the cytoplasm in iPSC-derived neurons, leading to KRAB-specific degradation, and shows that adding a neuronal-specific NLS restores nuclear localization and expression.

3 citations

humanCRISPR screen

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GeneticsbioRxivPreprintJun 26, 2023

High density SNP array and reanalysis of genome sequencing uncovers CNVs associated with neurodevelopmental disorders in KOLF2.1J iPSCs

Carolina Gracia-Diaz, Jonathan Elliot Perdomo, Munir E. Khan…·Naiara Akizu

The paper identifies CNVs in KOLF2.1J iPSCs linked to neurological disorders, showing they arose in vitro and affect gene expression in neural cells.

3 citations

humanwhole-genome sequencing

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