Nima N. Naseri

This study identifies that dCas9-KRAB mislocalizes to the cytoplasm in iPSC-derived neurons, leading to KRAB-specific degradation, and shows that adding a neuronal-specific NLS restores nuclear localization and expression.

The paper introduces CellAligner, a framework to robustly compare subcellular protein organization across morphologically distinct cells, improving classification accuracy in neuronal imaging.

This study shows that tau phosphorylation patterns influence microtubule stability, with specific phosphorylations impairing tau's ability to counteract destabilization, suggesting phosphorylation may respond to, rather than precede, MT instability.