Regulatory T cells restrain skin inflammation by modulating peripheral neuron activation
Alejandra Mendoza, Regina Bou-Puerto, Juan Sebastián Jara, Stanislav Dikiy, Paolo Giovanelli, Danilo Correa, Susanna Manenti, Emma S. Andretta, Chitra Lekha Dahia, Alexander Yu Rudensky
This study shows that regulatory T cells modulate peripheral neuron activation to restrain skin inflammation by expressing Penk, a precursor for endogenous opioids.
Science Immunology · Sep 5, 2025Peer-reviewedImmunology