Tomoyasu Matsubara

The paper identifies APOE rare missense variants in the Japanese population and finds two variants associated with protective effects against Alzheimer's disease.

This study determines the structure of α-synuclein filaments in multiple system atrophy using cryo-EM, revealing distinct filament types and conformers that differ from in vitro assemblies.

This paper reports the structure of tau filaments in corticobasal degeneration using cryo-EM, revealing a novel four-layered fold distinct from other tauopathies.