Takeshi Ikeuchi

This study identifies GPR34 as a regulator of microglial amyloid β fibril uptake, showing that its agonist enhances fibril clearance and that its expression declines with age and AD progression.

The paper identifies APOE rare missense variants in the Japanese population and finds two variants associated with protective effects against Alzheimer's disease.

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

The paper describes MRI and PET protocols used in the DIAN study to investigate preclinical Alzheimer's disease and reports key imaging findings.

Cryo-EM structures sort four-repeat tauopathies into three-layered (PSP, GGT, LNT) and four-layered (CBD, AGD, ARTAG, MAPT intron 10 mutations) tau folds, grounding a hierarchical structure-based classification.

The paper shows that age-related DNA demethylation in the TARDBP 3'UTR reduces alternative splicing and increases TARDBP mRNA expression in the human motor cortex, linking this to earlier ALS onset.

This study identifies two new potential susceptibility genes for late-onset Alzheimer's disease in East Asians through APOE-stratified GWAS.

The paper identifies RAC1 as a key gene in Alzheimer's disease progression through a protein domain network analysis and validates its role using Drosophila models and miRNA regulation.

This paper reports the structure of tau filaments in corticobasal degeneration using cryo-EM, revealing a novel four-layered fold distinct from other tauopathies.

The paper identifies enhancer variants linked to Alzheimer's disease that influence gene expression through chromatin looping mechanisms.